Mechanisms of HBV-related hepatocarcinogenesis
نویسندگان
چکیده
منابع مشابه
Fumonisin-induced hepatocarcinogenesis: mechanisms related to cancer initiation and promotion.
We review the hepatocarcinogenic effects of fungal cultures of Fusarium verticillioides(= Fusarium moniliforme) strain MRC 826 in male BD IX rats. Subsequent chemical analyses of the fumonisin B (FB) mycotoxin content in the culture material used and long-term carcinogenesis studies with purified FB1 provide information about dose-response effects, relevance of hepatotoxicity during FB1-induced...
متن کاملRegulatory mechanisms for HBV replication
Hepatitis B virus (HBV) is one of the smallest enveloped DNA viruses and infects more than 350 million people worldwide. HBV infection causes acute and chronic hepatitis, and is one of the major causes of cirrhosis and hepatocellular carcinoma. Currently available therapies can achieve viral suppression, but not termination of HBV infection. HBV replicates its genome via an RNA intermediate in ...
متن کاملGene expression analysis in HBV transgenic mouse liver: a model to study early events related to hepatocarcinogenesis.
Hepatitis B virus (HBV) is one of the major etiological factors responsible for the development of hepatocellular carcinoma (HCC). We used a transgenic mouse, containing HBV sequences, as a model system to unravel the molecular mechanisms of hepatocarcinogenesis induced by HBV. We chose this animal model because it consistently develops liver cancer after intermediate steps that mimic the natur...
متن کاملMicroRNAs Associated With HBV Infection And HBV-related HCC
Hepatitis B virus (HBV) infection is a global problem and a major risk factor for hepatocellular carcinoma (HCC). microRNAs (miRNAs) comprise a group of small noncoding RNAs regulating gene expression at the posttranslational level, thereby participating in fundamental biological processes, including cell proliferation, differentiation, and apoptosis. In this review, we summarize the roles of m...
متن کاملUpregulation of DARS2 by HBV promotes hepatocarcinogenesis through the miR-30e-5p/MAPK/NFAT5 pathway
BACKGROUND Infection with the hepatitis B virus (HBV) is closely associated with the development of hepatocellular carcinoma (HCC). The osmoregulatory transcription factor nuclear factor of activated T-cells 5 (NFAT5) has been shown to play an important role in the development of many types of human cancers. The role of NFAT5 in HBV-associated HCC has never previously been investigated. METHO...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Hepatology
سال: 2010
ISSN: 0168-8278
DOI: 10.1016/j.jhep.2009.10.033